The calciferol receptor (VDR) is a proteins that is triggered by calciferol. It is interested in maintaining the mineral stability in the body and adding to growth and hair production. It also treats adipose tissues.

VDRs will be expressed inside the parathyroid glands, intestines, epithelial cells, and many the immune system cell types. They are thought to regulate the intestinal compression of calcium mineral, and to mediate some of the associated with vitamin D in bone repair. Also, they are thought to perform an important function in metabolism.

VDR can be found in a variety of tissues, including epithelial cells, macrophages, neutrophils, and skin keratinocytes. However , they are really most widely stated in the kidneys and bone tissues.

The VDR is phosphorylated in serine elements by many protein kinases. These kinases include PKA and PKC. The effect worth mentioning kinases in VDR is normally ligand based. Specifically, the phosphorylation of Ser51 by PKC reduced VDR nuclear localization. Likewise, phosphorylation of Ser182 by PKA reduced RXR heterodimerization.

Studies have shown that VDRs are present in a subset of glial cells, especially in oligodendrocytes in white subject. Although VDR immunoreactivity has been discovered in a number of glial cell lines, no evidence has been presented that the occurrence of VDR in glia is a cause of increased likelihood of tumorigenesis.

In addition , VDR looks present in a subset of neurons. Actually nuclear staining has been proven in our cortex and glial cell-lines.

A large 220-kDa protein can be found in human primary glioblastoma cells. In contrast, a small recombinant VDR-like protein was produced.